Companies in the Industrial Goods sector have received a lot of coverage today as analysts weigh in on Dana Holding (DAN – Research Report)

Analysts Conflicted on These Industrial Goods Names: Dana Holding (DAN) and Mohawk (MHK)

Dana Incorporated (NYSE:DAN) reported third-quarter FY23 sales growth of 5% year-on-year to $2.669 billion, missing the consensus of $2.695 billion. Adjusted EPS of $0.30 beat the analyst consensus of $0.13.

Dana Overcomes Challenges With Q3 EPS Beat But Foresees $500M Sales Drop If No UAW Strike Resolution By Year's End

On a per-share basis, the Maumee, Ohio-based company said it had net income of 13 cents. Earnings, adjusted for one-time gains and costs, were 30 cents per share. The results beat Wall Street expectations. The average estimate of three analysts surveyed by Zacks Investment Research was for earnings of 10 cents per share.

Dana: Q3 Earnings Snapshot

Axle supplier outlines a potential $500 million swing in revenue depending on when the UAW strikes conclude. Full-year revenue could range from $10.2 billion to $10.7 billion, Dana said.

Dana sees 'significant impact' from UAW strikes, but swings to Q3 profit

Over the last four quarters, the company has surpassed consensus EPS estimates three times. Dana, which belongs to the Zacks Automotive - Original Equipment industry, posted revenues of $2.67 billion for the quarter ended September 2023, missing the Zacks ...

Dana (DAN) Q3 Earnings Top Estimates

Auto parts supplier Dana said on Friday its operations in North America were "significantly impacted" by the ongoing United Auto Workers (UAW) union strikes against automakers, while outlining the expected financial hit from them.

Dana sees 'significant impact' from UAW strikes to North American operations

Dana Incorporated announced the addition of Ultimate Dana 80 bracketless crate axles that allow for easy installation on virtually any application. The axles have ultra-strong four-inch tubes with 5/8-inch wall thickness and Spicer 40 spline nickel ...

Dana adds bracketless crate axels

Dana White's Contender Series Season 7 premieres on Tuesday, Aug. 8 at 7 p.m. on ESPN+. Photo by Chris Unger/Zuffa LLC "Dana White's Contender Series," which is in Season 7, has been the path for ...

'Dana White's Contender Series': Season 7 results

Get the most recent info and news about Dana on HackerNoon, where 10k+ technologists publish stories for 4M+ monthly readers.

Dana Incorporated provides power-conveyance and energy-management solutions for vehicles and machinery in North America, Europe, South America, and the Asia Pacific. It operates in four segments: Light Vehicle Drive Systems, Commercial Vehicle Drive and Motion Systems, Off-Highway Drive and Motion Systems, and Power Technologies. The Light Vehicle Drive Systems segment offers axles, driveshafts, e-axles, electrodynamic and drivetrain components, and transmissions, as well as electric, hybrid, and ICE products for light trucks, sport and crossover utility vehicles, vans, and passenger cars. The Commercial Vehicle Drive and Motion Systems segment provides axles, driveshafts, e-axles, e-transmissions, electrodynamic and drivetrain components, and electric vehicle integration services, as well as software as a service for medium and heavy duty trucks, buses, and specialty vehicles. The Off-Highway Drive and Motion Systems segment offers axles, driveshafts, transmissions, planetary hub drives, e-axles and e-drives, and helical and bevel-helical gearboxes, as well as electrodynamic, hydraulic, and drivetrain components for construction, earth moving, agricultural, mining, forestry, material handling, and industrial stationary markets. The Power Technologies segment offers gaskets and sealing, cover modules, heat shields, thermal management, e-thermal management, cooling, and bipolar fuel cell plates products for light vehicle, medium/heavy vehicle, and off-highway markets. The company was formerly known as Dana Holding Corporation and changed its name to Dana Incorporated in August 2016. Dana Incorporated was founded in 1904 and is headquartered in Maumee, Ohio.

Dana

HackerNoon editorial team has launched to celebrate their achievements and share their struggles. We need more women in technology, and by sharing stories, we can encourage many girls to follow their dreams. ! this interview series with women in tech Share your story today Tell us about yourself! I’m Dana Sydorenko, a Ukrainian entrepreneur best known as the co-founder of , a platform designed to connect gamers globally. Before my ventures in the tech industry, my background was in classical business. Also, I served as a paramedic in the Ukrainian Army and later transitioned my experience to the business sector by creating one of the largest military supply companies in Ukraine. I established myself as the founder and CEO of a few successful businesses and startups. GameTree Why did you choose this field in the first place? My way to tech was unexpected and fast. I served as a paramedic on the front line when I was 18, and after I got back to civil life, I felt very isolated and depressed. I started to play more MMO games, and they became my safe space, but often, instead of a safe and friendly community, I faced toxicity and harassment. I decided to change that. I believe there is nothing else like technology that could change the world and make it better. I fell in love with the idea of using algorithms to improve people's communities and connect people better. That's why I’m developing GameTree. It is not about games; it is about bringing people together. What tech are you most excited/passionate about right now and why? Right now, I'm enjoying the speed of the changes, and I am a futurist, dreaming about a world without government, without physical money, with self-driving cars and space travel, where we have more time for each other. A time when there is no inequality, sexism, racism, or wars. And if you say it’s impossible, I will answer that there are thousands of people building it right now. And some of us will succeed. Then, everyone will live in the new world that we are building for the next generations. What tech are you most worried about right now and why? I am concerned about how tech affects human social skills and mental health. Levels of diagnosed depression and suicidal rates go up every year. People need people, and technology should be here to help, not to make it worse, especially with everything moving toward AI interactions. I wonder if we're losing touch with the human element, and it will make us more isolated. What are your hobbies and interests outside of tech? Away from the tech world, I have a deep love for techno music; its rhythm and energy are a perfect escape for me. I also enjoy horse riding as I believe it is the best training for leadership and emotional intelligence, and also it is the best break from the digital life. Lately, I find happiness in sharing with others my experiences and mentoring in startup and tech programs for students, transferring my knowledge and insights to raise the next generation. Let's talk about breaking the glass ceiling. What were the biggest challenges you faced as a woman in tech, and how did you deal with them? I’ve often felt like I had to prove myself more. I felt that when you are a girl and you look too attractive, some people don’t take you seriously, so you need to look more like a man, think like a man, and behave like a man. Over time, I don’t have the energy to be concerned about people's thoughts and perspectives that much, rather, I show what I am worth through my actions and results. Hopefully, one day, it will be easier for girls like me to not be occupied with these situations or feelings at all. Any questionable misogynistic story/situation you faced/handled that you would like to share with the HackerNoon Fam? At the beginning of my career, I worked for a company with a very sexist boss, and I shared how difficult it is with a very inspiring woman, my mom. I asked her how she handles sexism when faced with it, and her answer became my credo. She said that she doesn't care what they think of her or her gender; she doesn’t care how they look at her or what they talk about behind her back. She does what she needs and what needs to be done and leaves people alone with their opinions. It's so simple, but it always works. What was the biggest setback/failure that you faced, and how did you manage it? I can’t say if it is my biggest failure. Probably, my biggest failure is still in front of me, but it is a situation that is hard for me personally and causes a lot of pain. As a war veteran in Ukraine, I served for a year as a paramedic on the front line, and when the Russian invasion started again, I felt a big responsibility to go back to the army, but GameTree really needed me too, and it was not an easy choice to make. It is a situation where all decisions lead to pain and loss. I still ask and blame myself for not fighting with my people. What's your biggest achievement that you're really proud of? I am proud of the teams and communities I was able to build. It makes me smile to see how the right people working, talking, or playing together are able to multiply each other’s strengths and cover each other’s weaknesses. My previous company became one of the largest military suppliers in Ukraine without me, and I am proud of them and proud I was able to bring these people together. Furthermore, GameTree's success belongs to the incredible people on the team. It is remarkable to see how together we are creating technology and products that change people's lives. We are receiving dozens of emails and messages about how we helped people meet someone who became their best friend or found the love of their life, and this is what makes me proud. I am honored to create these amazing teams and groups of people who, together, are able to do amazing things. In your opinion, why do we see this huge gender gap in the tech industry, and how can we reduce it? I see it is getting better, and I think the gap is about culture and stereotypes. Culturally, we are overprotecting girls and teaching them to be less risk-taking. Startups and Tech are is not just for men but for dreamers, for the bold and creative, those who are ready to take the initiative and be responsible for victories and mess-ups. We need to show young girls that tech isn’t just a 'guy thing.' It's about creativity, solving problems, and making a difference. Today, we are changing this by being visible role models and encouraging girls to go for it with us. Who is your tech idol? Why? My tech idol is not technically from the tech world (sorry for wordplay), but she inspires me a lot: Marie Curie. She broke barriers in science, showing the world what women can achieve against all odds. Her courage and determination are what I admire the most. As I mentioned before, one of the most remarkable women I know is my mom, a woman who taught me how to take risks, how to not be afraid of problems and complications, and how to be strong and unstoppable but smart and flexible. It is absolutely crucial to be surrounded by strong women so we can inspire each other and show how to get through difficult situations as a woman. Do you have any advice for aspiring girls who want to join the field? Follow your curiosity. Don’t let anyone tell you tech isn’t for you. You belong here as much as anyone. Your ideas, your creativity, they’re needed. Be messy if needed, be a troublemaker, be a rebel, make mistakes, and take risks. Be brave and look directly into the problems and difficulties with a beautiful female smile. We are waiting for you on this side.

Women in Tech: Dana Sydorenko creates connections to bring gamers together 

We’re excited to interview , whose article has recently become a on Hackernoon. Dana Kachan TOP Story So let’s start! Tell us a bit about yourself. I work as a strategic PR & marketing advisor to tech companies. I am also a business author and contributor to big media including HackerNoon, Entrepreneur, VentureBeat, and UX Magazine. I earlier worked as a Chief Marketing Officer of BullPerks (decentralized VC & crypto launchpad) and GamesPad (GameFi, NFT & metaverse ecosystem and launchpad). I have a track record in marketing advisory of high-tech and Web 3.0 startups all over the world. Along with other reputable experts, I contributed to a few research papers, including “ ” by GamesPad and “ ” by Divante and Kantar. Metaverse: Emerging Business Opportunities Global ECommerce Trends Interesting! What was your latest Hackernoon Top Story about? My latest story featured the innovative vision of who earlier collaborated with global brands such as Dior, Nike, and Porsche, as well as celebrities Justin Bieber, Steve Aoki, and others. luxury brands through the vintage cartoon aesthetics of the world-famous 3D artist Gal Yosef Do you usually write on similar topics? If not, what do you usually write about? The topic of art is pretty common to me. I’ve written a lot about .  Since I have extensive marketing and management experience, I often write about startup marketing, corporate life, and business in general. art and design on Medium Great! What is your usual writing routine like (if you have one?) Ideas for my articles are being born very organically. Acquiring experience and overcoming different challenges, I just feel the natural desire to share my findings with others. People who have ever worked with me know that I am very honest in my articles and share only what I really think. I have an extraordinary approach to content creation. It doesn’t look like anything that content writers and SEO specialists usually advise, and it might even meet criticism. Everything starts with the mission of the article. Before writing Op-Eds, I always question myself why should it matter to people. The internet is full of useless content, how to make mine different? How can it be particular? Based on that, I formulate the topic and start writing down a free flow of consciousness - a collection of my insights, thoughts, and conclusions. No structure. It's like a sketch on a bare canvas. Later, I structure all the content into an easy-to-understand article, adding statistics and interesting facts to back my concepts. Of course, this approach only works for Op-Ed articles and will unlikely work for businesses where everything requires a very clear structure. Being a writer in tech can be a challenge. It’s not often our main role, but an addition to another one. What is the biggest challenge you have when it comes to writing? The biggest challenge is to make an article thought-provoking. While sharing some professional insights, it’s also important to me to motivate people to read between the lines and understand important things that can bring change to our world. This is how viral content is usually born. It should resonate with people's pains and wants. What is the next thing you hope to achieve in your career? Nowadays, we can see many ambitious startups in clean tech, fintech, crypto, AI, and other emerging industries that are poised to become game-changers in the modern world. I want to be a part of this change and help these companies turn their inspirational ideas into reality, guiding them in marketing. My other goal is to become an educator and share my insights with like-minded people. I am actively moving in this direction, joining startup accelerators as a mentor. Wow, that’s admirable. Now, something more casual: What is your guilty pleasure of choice? I try to keep a healthy lifestyle, but sometimes, I give in to the temptation to eat something sweet like chocolate, ice cream, or cakes. :) Do you have a non-tech-related hobby? If yes, what is it? I like walking or jogging near the sea. It’s really relaxing and helps clear the mind. What can the HackerNoon community expect to read from you next? I can only say that I will try to make something extraordinary, educational, and definitely worth your time to read it. What’s your opinion on HackerNoon as a platform for writers? HackerNoon is a very progressive platform. I like the content you pick for publishing. As a marketer, I am really amazed by your newsletters. They are so creative, fun, and catchy! Thanks for taking the time to join our “ ” series. It was a pleasure. Do you have any closing words? Meet the writer Thank you for this opportunity! HackerNoon is a great magazine, and it’s a great pleasure for me to be one of your contributors and share my insights with your readers. Thanks once again!

Meet HackerNoon Contributor Dana Kachan: A Strategic Marketing Consultant & Startup Advisor 

Legendary Harlem-based fashion innovator and influencer Dapper Dan partners with Gap to launch his first NFT collection announced a limited-edition collection of non-fungible tokens (NFTs) designed in collaboration with legendary fashion innovator and style influencer, Dapper Dan. The launch will build on the gamification of its first NFT launch, allowing customers to build their NFT collection with several drops at various levels and price points. This event marks the adoption of NFT by the fashion industry as a means to provide gamified customer experience to its customers. Gap Gap and Dapper Dan have just released two special-edition DAP GAP collaborations, and now they're taking the partnership a step further by collaborating on a limited edition NFT collection, as well as a "Harlem Tailor" hoodie and a one-of-a-kind varsity jacket—a first-time NFT partnership for Dapper Dan." One-of-a-Kind DAP GAP digital art made by Dapper Dan and a limited-edition physical DAP GAP varsity jacket autographed by Dap himself are up for sale during the 48-hour NFT event beginning on April 2 at 9 a.m. PT/12 p.m. ET. The auction begins on the same day as the inaugural annual fundraiser in New York City for Fifteen Percent Pledge. An advocacy group, the Fifteen Percent Pledge, will receive all the auction proceeds, which will be given to Gap Inc. to support its commitment to creating access and opportunity for the Black community by increasing its pipeline programmes by 15 percent, through the fiscal sponsor, Philanthropic Ventures Foundation. The experience will include three gamified level drops following the auction: Common, Rare and Epic. Starting on April 5, Common will be on sale for 48 hours, for 2 Tez (XTZ). Currently, 2 Tez is roughly $7 USD Rare will be on sale starting April 7 for 10  Tez and Epic on April 12 for 100 Tez. All levels will be available to shop exclusively on at 9 am PT / 12 pm ET. The digital collectables will be available on a first-come, first-served basis, with Rare and Epic levels available in more limited editions. (exact conversion rates may vary based on market price fluctuations). gap.com/nft The gamified experience encourages customers to collect iconic Gap hoodie digital art at the Common and Rare levels to unlock the opportunity to purchase the Epic—limited edition digital art designed by Dapper Dan and a special-edition physical DAP GAP Epic “Harlem Tailor” hoodie. For those who participated in the first Metallic series drop in January (Series 1), there are several perks they can expect: Metallic Series holders will receive one Dapper Dan Common NFT via Airdrop on 4/4 Metallic Series Epic holders will receive one Dapper Dan Rare NFT via Airdrop on 4/6 Preferred Access: 100 Dapper Dan Epic NFTs will be available for purchase on a first-come, first-served basis for holders with un-redeemed Metallic Series collector’s special (NFT created by fusing four Common and two Rare Metallic Series NFTs) beginning at 8 am PT on 4/12, one hour before they are available to the public Simultaneously with this drop, Gap is also announcing a new Discord server where customers can connect, engage, and foster a community with other fans of our NFTs. The Discord server can be accessed at . discord.gg/gapthreads Gap partners with and to create the Gap Threads marketplace, using a more energy efficient approach to secure its network, allowing it to operate with minimal energy consumption and a . Tezos Interpop low carbon footprint With Gap’s second venture into the metaverse, the company plans to continue testing and learning in this space. There will be future drops with a commitment to partnering with creators that mirror the brand’s values and push the boundaries of creativity. Don’t forget to like and share the story! The content of this story DO NOT represent the views of HackerNoon and are meant as information only from the lens of the independent contributor. Please DYOR before investing.

Dapper Dan, a Legendary Harlem-Based Fashion Innovator Debuts His First NFT Collection With GAP

The 2020 #Noonies are here, and they are both much greener and much bigger than last year. Among the 2,000+ deserving humans nominated across 5 categories for over 200 award titles, we discovered who’s has been nominated for a 2020 #Noonie in the Dana Kachan from Ukraine, Future Heroes and Technology categories. Without further ado, we present to you, our big techy world, from the perspective of Dana. 1.  Which 2020 Noonie have you been nominated for? Hacker Noon Contributor of the Year - PRODUCT DESIGN 2. Tell us a bit about yourself. Hi Hacker Noon! I'm so excited to appear on the list of your top contributors, it's a great honor to me. Thanks once again! A little about me: I'm a digital marketing strategist serving product design and development companies based in the USA, Singapore, and Europe. I'm also an author of many articles on design, product development, business, and marketing. 3. Tell us about the things you make / write / manage / build. Besides providing digital marketing consulting services for B2B businesses located in the USA, Singapore, and Europe, I try to be helpful and share my findings with other people via my articles. I'm also a UX design researcher and the co-author of the book "Business-Driven Digital Product Design" created collaboratively with Fireart Studio. Recently, I've become a contributing marketing expert at the 7th edition of Global eCommerce Trends Report 2020 created by Divante in collaboration with Kantar. After publishing my last article "What you need to know about digital marketing for the new normal" on E27, I have been invited to participate in a video podcast about marketing during the COVID-19 conducted by REL Communications (it's planned to be released soon). My recent articles have been published on your amazing magazine, as well as other online media, such as Yahoo News Singapore, The Designest, Noupe, ReadWrite, Business2Community, Creative Bloq, Usability Geek, Speakyboy Magazine, and E27. Networking with many product design&development companies, I often interview CEOs and Founders and include their opinions in my articles. So that I try to ensure readers always access tips and practices backed at my own digital marketing experience or experience of those incredible people who have grown their own products and companies. 4. What are you most excited about right now? I am excited to combine my passions for Design, Marketing, Digital Transformation, and Business topics, and write articles about UI/UX and graphic design in the context of marketing, the importance of design for business success, and how design intersects with customer psychology. 5. What are you worried about right now? My favorite Turkish food restaurant and clothing shop faced bankruptcy during the Coronavirus lockdown, so I am really worried about the future of all small businesses now. To support SMBs in these challenging times, I am now writing a articles on how they can boost their marketing to overcome a recession. 6. What's the most useful advice you've ever given somebody? The most useful advice? Likely, it was "Stop crying, be a strong man!" given to my small brother. The funniest thing is that instead of by brother, it has been sent to my boss by mistake on the first my working day, right after the final interview. 7. How has the pandemic changed your life and/or career? I have realized the significance of digital transformation for businesses even more than before since most of my clients have faced challenges related to it during a pandemic and were forced to adjust their businesses to new digital market rules. 8. If we gave you $10 million to invest in one thing right now, where would you put it? I would organize a 2-in-1 company - digital marketing agency + media production house (like Red Bull's one, including own magazine, radio, video production, etc) 9. What's an opinion you have that most people don't agree with? I believe in aliens. :) Since it would be too egocentric to think that we're alone in the whole Universe. 10. Which apps can't you live without? LinkedIn app, digital wallets 11. What are you currently learning? marketing approaches by Seth Godin For much the same reasons Hacker Noon decided not to put good ideas behind pop-ups or paywalls — nor abuse your personal data to target you with creepy ads — we also decided that you don’t have to be a #thinkfluencer or have 50k followers on Twitter to earn the recognition that comes with a 2020 Noonie Nomination. Make somebody’s day and nominate them to be recognized in the internet’s most independent and community-driven awards: . NOONIES.TECH

"Stop Crying, Be a Strong Man", Interview with Dana Kachan

The Power of Campaign Management in Driving Business Objectives and Checkout Success

A Comparative Algorithm Audit of Conspiracies on the Net: Results

This paper is available on under CC 4.0 license. Arxiv Authors: (1) Md Masud Rana, Department of Mathematics, University of Kentucky; (2) Duc Duy Nguyen, Department of Mathematics, University of Kentucky & ducnguyen@uky.edu. Table of Links Abstract & Introduction Datasets and Results Methods Conclusion, Data and Software Availability, Competing interests, Acknowledgments & References 4 Conclusion The study of protein-protein interactions (PPIs) and the prediction of mutation-induced binding free energy changes are of great importance in understanding the molecular basis of biological processes. The application of geometric graph theory and atom-level graph coloring techniques provides a powerful framework for analyzing biomolecules and capturing their intricate relationships. By utilizing the concept of geometric subgraphs and constructing multi-scale weighted colored geometric subgraphs (MWCGS), we can effectively represent the structural and functional properties of PPIs. The site-specific MWCGS features allow us to extract meaningful patterns and characteristics, shedding light on the effects of mutations and the underlying molecular interactions. In this work, we developed a mutation-induced binding free energy change predictor, called GGL-PPI, by incorporating site-specific MWCGS features for PPIs and gradient-boosting trees. Our method demonstrates superior performance compared to existing methods. The model was validated on three datasets: AB-Bind S645, SKEMPI 1.0 S1131, and SKEMPI 2.0 S4169 and S8338, showcasing its robustness and effectiveness. Furthermore, GGL-PPI was evaluated on a blind test set, the Ssym dataset. To prevent data leakage between the test and training sets, the model was trained on a homology-reduced balanced training set Q3488. This approach ensures the reliability and fairness of the evaluation process. GGL-PPI exhibits the most unbiased and superior performance in predicting binding free energy changes for both direct and reverse mutations, outperforming other existing methods, particularly for reverse mutations. Overall, the results highlight the potential of the GGL-PPI approach in accurately predicting mutation-induced binding free energy changes in protein-protein interactions, providing valuable insights into the molecular mechanisms underlying protein-protein interactions and facilitating drug design and discovery efforts. 5 Data and Software Availability The source code is available at Github: https://github.com/NguyenLabUKY/GGL-Mutation. 6 Competing interests No competing interest is declared. 7 Acknowledgments This work is supported in part by funds from the National Science Foundation (NSF: # 2053284, # 2151802, and # 2245903), and the University of Kentucky Startup Fund. References [1] Dana Chuderland and Rony Seger. Protein-protein interactions in the regulation of the extracellular signal-regulated kinase. Mol. Biotechnol., 29:57–74, 2005. [2] Harry Jubb, Tom L Blundell, and David B Ascher. Flexibility and small pockets at protein–protein interfaces: new insights into druggability. Prog. Biophys. Mol., 119(1):2–9, 2015. [3] Mileidy W Gonzalez and Maricel G Kann. Chapter 4: Protein interactions and disease. PLoS Comput. Biol., 8(12):e1002819, 2012. [4] Cunliang Geng, Li C Xue, Jorge Roel-Touris, and Alexandre MJJ Bonvin. Finding the δδg spot: are predictors of binding affinity changes upon mutations in protein–protein interactions ready for it? Wiley Interdiscip. Rev. Comput. Mol. Sci., 9(5):e1410, 2019. [5] Rocco Moretti, Sarel J Fleishman, Rudi Agius, Mieczyslaw Torchala, Paul A Bates, Panagiotis L Kastritis, Joao PGLM Rodrigues, Mika¨el Trellet, Alexandre MJJ Bonvin, Meng Cui, et al. Community-wide evaluation of methods for predicting the effect of mutations on protein–protein interactions. Proteins: Struct. Funct. Genet., 81(11):1980–1987, 2013. [6] Jeffrey R Brender and Yang Zhang. Predicting the effect of mutations on protein-protein binding interactions through structure-based interface profiles. PLoS Comput. Biol., 11(10):e1004494, 2015. [7] Ning Zhang, Yuting Chen, Haoyu Lu, Feiyang Zhao, Roberto Vera Alvarez, Alexander Goncearenco, Anna R Panchenko, and Minghui Li. Mutabind2: predicting the impacts of single and multiple mutations on protein-protein interactions. Iscience, 23(3):100939, 2020. [8] Carlos HM Rodrigues, Yoochan Myung, Douglas EV Pires, and David B Ascher. mcsm-ppi2: predicting the effects of mutations on protein–protein interactions. Nucleic Acids Res., 47(W1):W338–W344, 2019. [9] Minghui Li, Marharyta Petukh, Emil Alexov, and Anna R Panchenko. Predicting the impact of missense mutations on protein–protein binding affinity. J. Chem. Theory Comput., 10(4):1770–1780, 2014. [10] Hafumi Nishi, Manoj Tyagi, Shaolei Teng, Benjamin A Shoemaker, Kosuke Hashimoto, Emil Alexov, Stefan Wuchty, and Anna R Panchenko. Cancer missense mutations alter binding properties of proteins and their interaction networks. PloS one, 8(6):e66273, 2013. [11] Mu Gao, Hongyi Zhou, and Jeffrey Skolnick. Insights into disease-associated mutations in the human proteome through protein structural analysis. Structure, 23(7):1362–1369, 2015. [12] Alessia David, Rozami Razali, Mark N Wass, and Michael JE Sternberg. Protein–protein interaction sites are hot spots for disease-associated nonsynonymous snps. Hum. Mutat., 33(2):359–363, 2012. [13] H Billur Engin, Jason F Kreisberg, and Hannah Carter. Structure-based analysis reveals cancer missense mutations target protein interaction interfaces. PLoS One, 11(4):e0152929, 2016. [14] Amelie Stein, Douglas M Fowler, Rasmus Hartmann-Petersen, and Kresten Lindorff-Larsen. Biophysical and mechanistic models for disease-causing protein variants. Trends Biochem. Sci., 44(7):575–588, 2019. [15] Stephanie Portelli, Jody E Phelan, David B Ascher, Taane G Clark, and Nicholas Furnham. Understanding molecular consequences of putative drug resistant mutations in mycobacterium tuberculosis. Sci. Rep., 8(1):1–12, 2018. [16] Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, et al. Structural implications of mutations conferring rifampin resistance in mycobacterium leprae. Sci. Rep., 8(1):5016, 2018. [17] Vytautas Gapsys, Servaas Michielssens, Daniel Seeliger, and Bert L de Groot. Accurate and rigorous prediction of the changes in protein free energies in a large-scale mutation scan. Angew. Chem., Int. Ed., 55(26):7364–7368, 2016. [18] Elizabeth H Kellogg, Andrew Leaver-Fay, and David Baker. Role of conformational sampling in computing mutationinduced changes in protein structure and stability. 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